2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate
CAS: 786647-50-5
Molecular Formula: C17H21NO4
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate - Names and Identifiers
| Name | 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate |
| Synonyms | ETHYL N-BOC-(INDOL-3-YL)ACETATE 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate 1H-Indole-3-acetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester |
| CAS | 786647-50-5 |
| InChI | InChI=1S/C17H21NO4/c1-5-21-15(19)10-12-11-18(16(20)22-17(2,3)4)14-9-7-6-8-13(12)14/h6-9,11H,5,10H2,1-4H3 |
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C17H21NO4 |
| Molar Mass | 303.35 |
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate - Introduction
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate is an organic compound whose chemical formula is C18H23NO4. It has the following properties:
-Appearance: colorless or light yellow liquid
-Melting point: 35-37°C
-Boiling point: 110-112°C
-Density: 1.06 g/mL
-Solubility: Soluble in organic solvents, such as ethanol, toluene and dichloromethane, insoluble in water.
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate is commonly used as an intermediate in organic synthesis and has the following uses:
-Drug research: as an important intermediate for the preparation of drugs containing indole structure, such as tumor treatment drugs.
-Chemical synthesis: used to synthesize other organic compounds, such as nitrogen-containing heterocyclic compounds and natural products.
In terms of preparation, 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate can be prepared by the following steps:
1. take indole -3-acetic acid and 2-methyl -2-propanol reaction, generate indole -3-acetic acid 2-methyl -2-propanol ester.
2. In the presence of potassium carbonate, the product is esterified with N-Boc imine to give 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate.
Note the following safety information when using 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate:
-It may be irritating and harmful, avoid contact with skin, eyes and respiratory tract.
-Wear appropriate protective equipment such as gloves, goggles and protective clothing when used.
-Operate in a well-ventilated place to avoid inhaling its vapors.
-Store it in a cool, dry place, away from fire and oxidizing agents.
-Appearance: colorless or light yellow liquid
-Melting point: 35-37°C
-Boiling point: 110-112°C
-Density: 1.06 g/mL
-Solubility: Soluble in organic solvents, such as ethanol, toluene and dichloromethane, insoluble in water.
2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate is commonly used as an intermediate in organic synthesis and has the following uses:
-Drug research: as an important intermediate for the preparation of drugs containing indole structure, such as tumor treatment drugs.
-Chemical synthesis: used to synthesize other organic compounds, such as nitrogen-containing heterocyclic compounds and natural products.
In terms of preparation, 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate can be prepared by the following steps:
1. take indole -3-acetic acid and 2-methyl -2-propanol reaction, generate indole -3-acetic acid 2-methyl -2-propanol ester.
2. In the presence of potassium carbonate, the product is esterified with N-Boc imine to give 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate.
Note the following safety information when using 2-Methyl-2-propanyl 3-(2-ethoxy-2-oxoethyl)-1H-indole-1-carboxylate:
-It may be irritating and harmful, avoid contact with skin, eyes and respiratory tract.
-Wear appropriate protective equipment such as gloves, goggles and protective clothing when used.
-Operate in a well-ventilated place to avoid inhaling its vapors.
-Store it in a cool, dry place, away from fire and oxidizing agents.
Last Update：2024-04-09 21:50:46
